Last updated:3rd April 2018

Certolizumab pegol (Cimzia)

Certolizumab pegol (Cimzia) is an anti TNF is an anti TNF which has been approved by NICE for AS and non radiographic axial spondyloarthritis.

Certolizumab pegol is only available on prescription from a consultant rheumatologist.

It is taken by an injection under the skin using a pre-filled syringe. You, your partner, or another member of your family are shown how to do the injection. If this is not possible, the injections can be given by your rheumatology nurse specialist or district nurse.

When you start certolizumab pegol you need to do two injections every 2 weeks for the first 6 weeks and from then on it is one injection every 2 weeks.

If you are being prescribed certolizumab pegol it is recommended that you carry a biological therapy alert card, which you can get from your doctor or rheumatology nurse. Then if you become unwell, anyone treating you will know that you are on certolizumab pegol and that you are therefore at risk of its side-effects, including infections.

Time certolizumab pegol takes to work

If you respond to certolizumab pegol your symptoms will start to improve in 2-12 weeks.

Possible side effects

Reactions at the injection site such as redness, swelling or pain may occur. These reactions are not usually serious. Changing the injection site will help reduce the chances of a reaction.

Certolizumab pegol lowers the immune system and so you may be more likely to develop infections.

Avoid close contact with people with infections and be extra careful with food safety.

Contact your doctor or rheumatology nurse straight away if you develop any of the following symptoms:

  • sore throat
  • fever
  • other symptoms of infection such as coughing up green phelgm or diarrhoea
  • new symptoms or anything else that concerns you.

You should stop Certolizumab pegol and see your doctor immediately if:

  • any of the symptoms listed above are persistant or severe
  • you have not had chickenpox and you come into contact with someone who has chickenpox or shingles
  • you develop chickenpox or shingles.

Chickenpox and shingles can be severe in people who are on treatments that affect the immune system such as certolizumab pegol. You may need antiviral treatment, which your doctor will be able to prescribe and you will need to stop ertolizumab pegol until you are better.

In rare cases, people may have an allergic reaction to certolizumab pegol.

Potential risks associated with certolizumab pegol

Anti-TNF therapy has been associated with some types of skin cancer. These can be readily treated when diagnosed early. Research so far hasn’t confirmed an increased risk of other cancers.

Very rarely, people taking certolizumab pegol may develop a condition called drug induced lupus. This is usually mild and can be diagnosed by a blood test. Symptoms include a rash, fever and increased joint pain. If you develop drug-induced lupus, the certolizumab pegol will be stopped and the condition then usually disappears.


If you're taking certolizumab pegol it's recommended that you avoid live vaccines such as yellow fever. If you do need a live vaccine do discuss all the possible risks and benefits of the vaccination with your doctor.

If you're in your 70s your doctor may advise you to have the shingles vaccination (Zostavax) before starting certolizumab pegol. This vaccination is not recommended for people who are already on certolizumab pegol.

Pneumovax (pneumonia) and yearly flu vaccines are recommended for everyone on certolizumab pegol.

Other medicines

Certolizumab pegol may be prescribed along with other medicines. Do discuss any new medications with your doctor before starting them, and always tell any doctor treating you that you are on certolizumab pegol.

Certolizumab pegol is not a painkiller. If you are already on a non-steroidal anti inflammatory drug (NSAID) or painkillers you can carry on taking these as well as certolizumab pegol, unless your doctor advises otherwise.

Do not take over-the-counter preparations or herbal remedies without discussing this first with your doctor, rheumatology nurse or pharmacist.


There is no known interaction between certolizumab pegol and alcohol.

Certolizumab pegol and surgery

If you are going to have an operation please inform your doctor, as you are likely to be advised to stop the certolizumab pegol  temporarily before and after surgery.

Certolizumab pegol and pregnancy

The British Society for Rheumatology produced new guidelines on the use of anti TNF therapy such as certolizumab pegol during pregnancy.

Certolizumab pegol and travelling

If you are travelling abroad and taking your anti TNF therapy with you, it's important to make plans to keep it at the correct temperature during the journey and at your destination. You can buy special cool bags and even travel fridges. A useful company to try to purchase these products is MedActiv.

Another option is to use a Frio wallet or carry case. These are designed to keep insulin cool but work well for anti TNF. You can buy these through Amazon.

In addition to your anti TNF medication you may require a travel size sharps box. Do discuss this with your Clinical Nurse Specialist or your delivery team.

There's more travel tips in the `Living with AS` section of the website.




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