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axial SpA (AS) medication

Your Medication

Learn about the medications used to manage axial SpA

This information is for anyone with axial spondyloarthritis (axial SpA) including people with ankylosing spondylitis (AS)

Axial SpA medications are used to improve your symptoms

Depending on the severity of your axial SpA your doctor may need to give you a combination of medications to help you with the pain, stiffness and inflammation.

If you are having a flare you may want to talk to your GP or rheumatologist about altering your medication.

Medicines used to treat axial SpA include

Analgesics (painkillers). These reduce pain and are often used together with other medications.

Non-steroidal anti-inflammatory drugs (NSAIDs). These medications reduce inflammation as well as pain. Again, they are often used alongside other medications.

Corticosteroids (steroids). These drugs can be effective in controlling inflammation but can cause short and long term side effects. They can be used in the form of local injections into joints or in tablet form.

Disease modifying anti-rheumatic drugs (DMARDs). These can reduce pain, stiffness and swelling in people who have symptoms in peripheral areas such as the hips, knees, ankles or wrists. There is no evidence DMARDs will help with pain in the spine (axial disease).

Nerve pain medication. These medications specifically help people who suffer from long term nerve pain. This type of pain is caused by some damage to or pressure on nerves. Nerve pain is often described by people as being like ‘shooting pains’, ‘electric shocks’, ‘tingling’ or ‘the sensation of crawling under the skin’. Amitriptyline is the most commonly used medication in this group.

Biologic therapy. There are two types of biologic therapy (anti IL 17A and anti TNF therapy) which have been licensed to treat axial SpA  and are approved by NICE. Both work by reducing the inflammation produced by the body. New types of biologic therapy are in development and going through clinical trials.

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About AS - Genetics Research

Biologic Therapy

Two types of biologic therapy have been licensed to treat axial SpA (AS) by NICE. Both work by reducing inflammation produced by the body

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People Nurse


DMARDs can reduce pain and stiffness in peripheral areas such as the knees but there is no evidence they help with the spine

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