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Discover the role of biosimilars in the treatment of axial SpA (AS)

This information is for anyone with axial spondyloarthritis (axial SpA) including people with ankylosing spondylitis (AS)

Biosimilar medicines are developed to be highly similar to a biologic medicine

They can be developed by manufacturers once the original patent for the product has expired.

They are called “biosimilar” because the molecular structures are so complex that it is not possible to produce an absolutely identical drug to the original – referred to as the “originator”. With smaller drugs, such as non-steroidal anti-inflammatory drugs, it is common for different manufacturers to produce identical “copies” of the originator drug, known as “generic” drugs.

Why make biosimilars?

Biosimilar medicines are developed in order to provide alternative products, usually at a lower cost than the original biological medicine.

Regulations for biosimilar medications

Once approved, a biosimilar medicine is recognised to be a highly similar version of a biological medicine and should have comparable quality, safety and effectiveness.

Biosimilars introduced into the UK market first have to be approved by the European Medicines Agency (EMA). They go through a regulatory process which requires comparability studies that demonstrate equivalence to the originator product in terms of quality, efficacy and safety.

Our recommendations

We know that since of launch of biosimilars, a lot of rheumatology departments have taken the decision to move people from originator drugs to the biosimilar. This is because the biosimilar is less expensive. If you have been contacted by your rheumatology department about switching we would expect:

  • The initial letter or contact should include information about the new medication
  • There should be an opportunity for you to discuss the switch in more detail – whether that’s in a group meeting or a one to one discussion with a member of your rheumatology team
  • Training on the new device should be offered

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About AS - Genetics Research

Biologic Therapy

Two types of biologic therapy have been licensed to treat axial SpA (AS) by NICE. Both work by reducing inflammation produced by the body

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